White adipose tissue dysfunction: pathophysiology and emergent measurements

Biblioteca

White adipose tissue dysfunction: pathophysiology and emergent measurements

White adipose tissue dysfunction: pathophysiology and emergent measurements
2023
Acusar erro

Ficha da publicação

Nome da publicação: White adipose tissue dysfunction: pathophysiology and emergent measurements

Autores: Natalia Santillana, Camila Astudillo-Guerrero, Amanda D’Espessailles, Gonzalo Cruz

Fonte: Nutrients

Publicado em: 2023

Tipo de arquivo: Artigo de periódico

Link para o original

Resumo

White adipose tissue (AT) dysfunction plays an important role in the development of cardiometabolic alterations associated with obesity. AT dysfunction is characterized by the loss of the expansion capacity of the AT, an increment in adipocyte hypertrophy, and changes in the secretion profile of adipose cells, associated with accumulation of macrophages and inflammation. Since not all people with an excess of adiposity develop comorbidities, it is necessary to find simple tools that can evidence AT dysfunction and allow the detection of those people with the potential to develop metabolic alterations. This review focuses on the current pathophysiological mechanisms of white AT dysfunction and emerging measurements to assess its functionality