Summary

While genetic studies have identified hundreds of loci associated with adiposity, the phenotypic expression of this individual genetic risk is not fixed but dependent on environmental circumstances. Socioeconomic Position (SEP), which includes education, income, and area-level deprivation, serves as an important environmental modulator of genetic liability. However, the literature on Gene-Environment (G×E) interactions remains fragmented, particularly regarding how these evolve across the life course.
Lower educational attainment and socioeconomic deprivation appear to amplify genetic susceptibility to obesity, although evidence remains heterogeneous in PRS construction, SEP operationalization, outcome definition, ancestry, and analytical framework. Emerging evidence suggests educational attainment and early-life socioeconomic conditions may represent modifiable contexts influencing genetic obesity risk across the life course.