Summary

Oxidative stress plays a critical role in age-related pathophysiology, and postmenopausal women are particularly vulnerable due to hormonal and metabolic changes. Although dietary quality has been implicated in modulating oxidative balance, few studies have explored whether obesity mediates this relationship in this population, representing a novel perspective in dietary-oxidative research.
Our findings reveal a significant mediating role of obesity in the relationship between diet and oxidative stress in postmenopausal women. These results underscore the importance of integrated dietary and weight management strategies—such as promoting antioxidant-rich diets and obesity prevention—in mitigating oxidative stress-related health risks in this population.